This is a free to use, central biomarker database which includes evidence on thousands of biomarker targets from blood serum and muscle tissue quantified via different technologies: mass spectrometry, aptamer-based protein screens, Affymetrix gene expression arrays, RT-PCR, etc. It provides easy access to cumulative knowledge in biomarkers for specific muscular dystrophies. Currently, this database includes data with a focus on serum proteins, but linked to muscle tissue biopsy based mRNA profiles.
• Provided with external links to UniProt, QuickGO, Human Protein Atlas for each biomarker.
• With information on the biomarker’s known involvement in other diseases and the MIM number.
The database focuses on Duchenne muscular dystrophy (to be expanded) and the following questions (more to be added):
• Which biomarkers behave similarly, i.e., have similar expression trends?
• Which biomarkers are different between boys with DMD and unaffected controls in serum and tissue?
• Which biomarkers respond to therapeutics, e.g., steroids?
• Which biomarkers are associated with age?
• Which biomarkers are associated with clinical outcomes?